• Health and Nutrition

Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER)

Research unit - UMR9020

Description

The main goal of the research unit is to better understand the mechanisms of resistance to cancer treatments. Using molecular and cell biology strategies, genetics, animal models and hospital biological resources, we investigate molecular mechanisms of resistance in solid tumors and hematologic malignancies and develop new diagnostic, prognostic and predictive markers for precision medicine. CANTHER is composed of 5 teams with specific and complementary expertises, competences and skill. We benefit from an outstanding scientific and technologic environment, and develop a pre-clinical and clinical research in close collaboration with clinicians. We are open to all academic and industrial collaborations and propose services in line with our expertise.

Contacts

  • Isabelle Van Seuningen
    Director

Informations

1, place de Verdun, Bâtiment Cancer
Campus Santé, Université de Lille
59045 LILLE

http://canther.fr/

Cancer Heterogeneity, Plasticity and Resistance to Therapies

Effectif

Effectif total : 112

Personnel d'appui à la recherche : 37

Expertises

Skills

• Resistance to anti-tumor targeted therapies
• Resistance to chemotherapy
• Resistance associated with the metastatic process
• Markers of resistance
• Senescence and fibrosis associated with resistance
• Mucins and cancer
• Cell plasticity and cancer
• Persistance of leukemic cells
• Tumor dormancy

Services offers

Applications sectors

  • Health / wellness
  • Science / Research

Services provided

• Screening of active compounds
• Validation of cancer models for specific studies
• Establishment of chemoresistant tumor models

Consulting services

We provide consulting services related to all our areas of expertise.

Equipments

Our unit is equipped with:
• cell culture rooms, BSL 2 and 3
• microscopes (electron, confocal, light sheet, fluorescent)
• qPCR and digital PCR machines
• flow cytometer
• microfluidic system to study the metastatic process
• IncuCyte live cell analysis system
• ultracentrifuge
• all the basic equipment (cell culture equipment, cell and molecular biology, etc.)

Ecosystem

Affiliated institutions / organisations

CHU de Lille
Inserm
University of Lille
CNRS

Partner institution(s)

Centre Oscar Lambret
Institut Pasteur de Lille

Doctoral schools

Competitive cluster

Regional strategic areas of activity

  • Health and Nutrition
    • Food ingredients
    • New therapeutic approaches

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Thematics

Current thematics

  • Health and Nutrition
    • Food ingredients
    • New therapeutic approaches
Title

Current content

Cancer Heterogeneity, Plasticity and Resistance to Therapies
Type

Current content

Research unit
Description

Current content

The main goal of the research unit is to better understand the mechanisms of resistance to cancer treatments. Using molecular and cell biology strategies, genetics, animal models and hospital biological resources, we investigate molecular mechanisms of resistance in solid tumors and hematologic malignancies and develop new diagnostic, prognostic and predictive markers for precision medicine. CANTHER is composed of 5 teams with specific and complementary expertises, competences and skill. We benefit from an outstanding scientific and technologic environment, and develop a pre-clinical and clinical research in close collaboration with clinicians. We are open to all academic and industrial collaborations and propose services in line with our expertise.
Contact informations
Contact

Current content

Contact name Email phone number
VAN SEUNINGEN Isabelle isabelle.vanseuningen@inserm.fr (+33) 3 20 29 88 67
URL

Current content

http://canther.fr/

Address

Current content

1, place de Verdun, Bâtiment Cancer
Campus Santé, Université de Lille
59045 LILLE
Keywords

Current content

cancer, therapy, resistance, dormancy, solid tumors, hematologic malignancies, senescence, fibrosis, stem cells, epigenetics
Our search domains
Skills

Current content

• Resistance to anti-tumor targeted therapies • Resistance to chemotherapy • Resistance associated with the metastatic process • Markers of resistance • Senescence and fibrosis associated with resistance • Mucins and cancer • Cell plasticity and cancer • Persistance of leukemic cells • Tumor dormancy
Workforce

Current content

Nombre de chercheurs :
Nombre de doctorants :
Nombre de personnel d'appui à la recherche : 37
Effectif total : 112
Example(s) of projects

Current content

Example(s) of publications

Current content

Collaborations/Partners/Scientific clients

Current content

Collaborations/Partners/Private Clients

Current content

Services offers
Training offers

Current content

Services offers

Current content

• Screening of active compounds • Validation of cancer models for specific studies • Establishment of chemoresistant tumor models
Consulting services

Current content

We provide consulting services related to all our areas of expertise.
Equipments
Equipements spécifiques

Current content

  • Automation system for IHC, double IHC and ISH tests
    BenchMark GX IHC/ISH/ Roche
  • Microscopy imaging platform
    Axioscan/ Zeiss
  • Flow analyzer
    Seahorse XF E24/ Agilent
  • Microplate reader
    Spectramax/ Molecular Devices
  • Live cell analysis system
    IncuCyte/ Sartorius
  • qPCR machine
    Aria Mx/ Agilent
  • Ultracentrifuge
    L70/ Beckman
Ecosystem
Affiliated institutions / organisations

Current content

  • CHU de Lille
  • Inserm
  • University of Lille
  • CNRS
Établissement(s) partenaire(s)

Current content

Centre Oscar Lambret Institut Pasteur de Lille
Unit(s) of attachment

Current content

Groups/Networks/Federations

Current content

Doctoral schools

Current content

Equipex/EquipEx+/ESR

Current content

Competitive cluster

Current content

Regional strategic areas of activity

Current content

  • Health and Nutrition
  • Food ingredients
  • New therapeutic approaches
Personal informations
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