• Bioeconomy
  • Chemistry and Materials
  • Health and Nutrition

Glycochemistry, Antimicrobials and Agro-Resources Laboratory (LG2A)

Research unit - UMR 7378

Description

In the field of glycochemistry, the research at LG2A is mainly devoted to the development of routes to molecules of interest from mono- and oligosaccharides obtained by chemical synthesis or by depolymerization of polysaccharides followed by functionalisation.

The research activity is structured in 2 Axes: Chemistry for Life / Chemobiology and Chemistry for Sustainable Development.

The Laboratory is placed at the centre of a dense map of research organisations, industries and networks, with projects supported or cofinanced by the ANR, the UE, the Hauts-de-France region, and SATT Nord.

Contacts

  • José KOVENSKY
    Director
  • Albert NGUYEN VAN NHIEN
    Deputy director
  • Carole DARGUESSE
    Secretary
  • Vincent CHAGNAULT
    Communication referent

Informations

10 rue Baudelocque
80039 AMIENS Cedex 1

https://www.u-picardie.fr/labo/LG/

Glycochemistry, Antimicrobials and Agro-Resources Laboratory

Effectif

Effectif total : 35

Personnel de recherche : 19

Personnel d'appui à la recherche : 7

Expertises

Skills

1. Axis Chemistry for Life / Chemobiology

• Antimicrobials: Sugar/lectin Interactions - Antimicrobial Glycoconjugates;
• Transport: Membrane transport in Gram-negative bacteria - Drug delivery;
• Synthetic methodology, oligosaccharides and analogues;
• Molecular modelling.

2. Axis Chemistry for Sustainable Development

• Energy: Organic materials for electrochemical storage -
Biosourced organic materials for photovoltaic cells
• Development of eco-compatible tools: Valorization of byproducts and biomass - Supported and biodegradable materials - Synthesis in non-conventional media -Polysaccharides

Example(s) of projects

1. H2020 ERA-NET Co-fund on Sustainable Food Production and Consumption SUSFOOD2 2018 :

SPAREC, Sustainable Processing of Agrofood Residues to Elicitors and Chemicals
Budget: 1 176 k€ total, 125 k€ LG2A
Partners: Universidad Complutense de Madrid (Madrid Complutense University) (Profs. Victoria Santos, coord, Miguel Ladero Galan), LG2A (Prof. José Kovensky), RISE-PFI Biocomposites (Dr. Gary Chinga Carrasco), ASA Spezialenzyme GmbH Germany (Dr. Arno Cordes),
PlantResponse S.L.Spain (Dr. Marise Borja), Pago de
Carraovejas R&D&i Spain (Dr. Eva Navascues), ELYS Conseil SASU France (Mr Yannick Le Guern)

2. ANR PRC 2018 : DEOSS, DEvelopment of Organic batteries with Solid-State electrolytes
Budget: 471 k€
Partners: LG2A (Dr. Franck Dolhem, coord), LRCS (Amiens), IMN (Nantes), IPREM (Pau)

3. ANR PRC 2017: OLIBLOCK, Oligosaccharidic (multi)block copolymers with tunable composition
Budget: 366 k€
Partners: LG2A (Prof. José Kovensky, coord, Dr. Véronique
Bonnet), IMP (Lyon, Prof. Eric Drockenmuller), ArminesCEMEF (Sophia-Antipolis, Dr. Patrick Navard)

4. ANR JCJC 2019: CARBOPHOTON Selective modification of carbohydrates using photo-activated nanocatalysts
Budget: 178 k€,
Partners: LG2A (Dr. G. Pourceau, MCF, coord, Pr. A. Wadouachi), LRCS (Dr. F. Sauvage, DR CNRS); LASIR Lille (Dr. Hervé Vezin, DR CNRS)

Example(s) of publications

1. Beneficial Health Effects of Glucosinolates-Derived Isothiocyanates on Cardiovascular and Neurodegenerative Diseases
Kamal, R. M.; Abdull Razis, A. F.; Mohd Sukri, N. S.; Perimal, E. K.; Ahmad, H.; Patrick, R.; Djedaini-Pilard, F.; Mazzon, E.; Rigaud, S.
Molecules 2022, 27, 624. 🡭

2. Cyclodextrin Complexation as a Way of Increasing the Aqueous Solublity and Staility of Carvedilol
Rigaud, S.; Mathiron, D.; Moufawad, T.; Landy, D.; Djedaini-Pilard, F.; Marçon, F.
Pharmaceutics 2021, 13, 1746. 🡭

3. Discrimination of isomeric trisaccharides and their relative quantification in honeys using trapped ion mobility spectrometry
Przybylski, C.; Bonnet, V.
Food Chem. 2021, 341, 128182.🡭

4. One-Pot Synthesis of Asymmetrically Difunctionalized Oligomaltosides by Cyclodextrin Ring Opening
Pélingre, M.; Smadhi, M.; Bil, A.; Bonnet, V.; Kovensky, J.
ChemistryOpen 2021, 10, 493-496. 🡭

5. Ring-Opening of Cyclodextrins: An Efficient Route to Pure Maltohexa-, Hepta-, and Octaoses
Pélingre, M.; Koffi Teki, D. S.-E.; El-Abid, J.; Chagnault, V.; Kovensky, J.; Bonnet, V.
Organics 2021, 2, 287-305.🡭


All publications can be found here : 🡭

Collaborations/Partners/Scientific clients

National: Université de Lille, Université de Lyon, Université de Nantes, Université de Pau et des Pays de l'Adour


International: Universidad Complutense de Madrid (Espagne)

Collaborations/Partners/Private Clients

Novance, Sanofi, Improve, Scient, URGO, Ocedis, Servier, SATT Nord

Services offers

Services provided

Services for all our expertise: Synthesis, Chromatography (HPLC, LC-MS, IC-MS, IR)

Training offers

Organic Synthesis - Purification - Separation - Analyses - Characterization - Enzyme inhibition tests (IC50, Ki)

Consulting services

We provide consulting services according to our expertise.

Equipments

All equipments can be found here : 🡭

Ecosystem

Affiliated institutions / organisations

CNRS

Groups/Networks/Federations

SFR Condorcet
EPNOE - European Polysaccharides Network of Excellence
ICP - Institut Chimie de Picardie

Doctoral schools

Competitive cluster

Regional strategic areas of activity

  • Bioeconomy
    • Biobased chemistry
    • Biobased materials
    • Sustainable production and mobilization of bioresources
  • Chemistry and Materials
    • Green chemistry
    • Organic chemistry
    • Textiles, composites, materials
  • Health and Nutrition
    • New therapeutic approaches

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Thematics

Current thematics

  • Bioeconomy
    • Biobased chemistry
    • Biobased materials
    • Sustainable production and mobilization of bioresources
  • Chemistry and Materials
    • Green chemistry
    • Organic chemistry
    • Textiles, composites, materials
  • Health and Nutrition
    • New therapeutic approaches
Title

Current content

Glycochemistry, Antimicrobials and Agro-Resources Laboratory
Type

Current content

Research unit
Description

Current content

In the field of glycochemistry, the research at LG2A is mainly devoted to the development of routes to molecules of interest from mono- and oligosaccharides obtained by chemical synthesis or by depolymerization of polysaccharides followed by functionalisation.

The research activity is structured in 2 Axes: Chemistry for Life / Chemobiology and Chemistry for Sustainable Development.

The Laboratory is placed at the centre of a dense map of research organisations, industries and networks, with projects supported or cofinanced by the ANR, the UE, the Hauts-de-France region, and SATT Nord.
Contact informations
Contact

Current content

Contact name Email phone number
KOVENSKY José jose.kovensky@u-picardie.fr
NGUYEN VAN NHIEN Albert albert.nguyen-van-nhien@u-picardie.fr
DARGUESSE Carole carole.darguesse@u-picardie.fr
CHAGNAULT Vincent vincent.chagnault@u-picardie.fr
URL

Current content

https://www.u-picardie.fr/labo/LG/

Address

Current content

10 rue Baudelocque

80039 AMIENS Cedex 1
Keywords

Current content

Glycochemistry, Chemical Synthesis, Functionalisation, Structural analysis, Antimicrobials, Molecular Interactions, Vectorization, Monosaccharides, Oligosaccharides, Polysaccharides
Our search domains
Skills

Current content

1. Axis Chemistry for Life / Chemobiology • Antimicrobials: Sugar/lectin Interactions - Antimicrobial Glycoconjugates; • Transport: Membrane transport in Gram-negative bacteria - Drug delivery; • Synthetic methodology, oligosaccharides and analogues; • Molecular modelling. 2. Axis Chemistry for Sustainable Development • Energy: Organic materials for electrochemical storage - Biosourced organic materials for photovoltaic cells • Development of eco-compatible tools: Valorization of byproducts and biomass - Supported and biodegradable materials - Synthesis in non-conventional media -Polysaccharides
Workforce

Current content

Nombre de chercheurs : 19
Nombre de doctorants :
Nombre de personnel d'appui à la recherche : 7
Effectif total : 35
Example(s) of projects

Current content

1. H2020 ERA-NET Co-fund on Sustainable Food Production and Consumption SUSFOOD2 2018 : SPAREC, Sustainable Processing of Agrofood Residues to Elicitors and Chemicals Budget: 1 176 k€ total, 125 k€ LG2A Partners: Universidad Complutense de Madrid (Madrid Complutense University) (Profs. Victoria Santos, coord, Miguel Ladero Galan), LG2A (Prof. José Kovensky), RISE-PFI Biocomposites (Dr. Gary Chinga Carrasco), ASA Spezialenzyme GmbH Germany (Dr. Arno Cordes), PlantResponse S.L.Spain (Dr. Marise Borja), Pago de Carraovejas R&D&i Spain (Dr. Eva Navascues), ELYS Conseil SASU France (Mr Yannick Le Guern) 2. ANR PRC 2018 : DEOSS, DEvelopment of Organic batteries with Solid-State electrolytes Budget: 471 k€ Partners: LG2A (Dr. Franck Dolhem, coord), LRCS (Amiens), IMN (Nantes), IPREM (Pau) 3. ANR PRC 2017: OLIBLOCK, Oligosaccharidic (multi)block copolymers with tunable composition Budget: 366 k€ Partners: LG2A (Prof. José Kovensky, coord, Dr. Véronique Bonnet), IMP (Lyon, Prof. Eric Drockenmuller), ArminesCEMEF (Sophia-Antipolis, Dr. Patrick Navard) 4. ANR JCJC 2019: CARBOPHOTON Selective modification of carbohydrates using photo-activated nanocatalysts Budget: 178 k€, Partners: LG2A (Dr. G. Pourceau, MCF, coord, Pr. A. Wadouachi), LRCS (Dr. F. Sauvage, DR CNRS); LASIR Lille (Dr. Hervé Vezin, DR CNRS)
Example(s) of publications

Current content

1. Beneficial Health Effects of Glucosinolates-Derived Isothiocyanates on Cardiovascular and Neurodegenerative Diseases Kamal, R. M.; Abdull Razis, A. F.; Mohd Sukri, N. S.; Perimal, E. K.; Ahmad, H.; Patrick, R.; Djedaini-Pilard, F.; Mazzon, E.; Rigaud, S. Molecules 2022, 27, 624. 🡭 2. Cyclodextrin Complexation as a Way of Increasing the Aqueous Solublity and Staility of Carvedilol Rigaud, S.; Mathiron, D.; Moufawad, T.; Landy, D.; Djedaini-Pilard, F.; Marçon, F. Pharmaceutics 2021, 13, 1746. 🡭 3. Discrimination of isomeric trisaccharides and their relative quantification in honeys using trapped ion mobility spectrometry Przybylski, C.; Bonnet, V. Food Chem. 2021, 341, 128182.🡭 4. One-Pot Synthesis of Asymmetrically Difunctionalized Oligomaltosides by Cyclodextrin Ring Opening Pélingre, M.; Smadhi, M.; Bil, A.; Bonnet, V.; Kovensky, J. ChemistryOpen 2021, 10, 493-496. 🡭 5. Ring-Opening of Cyclodextrins: An Efficient Route to Pure Maltohexa-, Hepta-, and Octaoses Pélingre, M.; Koffi Teki, D. S.-E.; El-Abid, J.; Chagnault, V.; Kovensky, J.; Bonnet, V. Organics 2021, 2, 287-305.🡭 All publications can be found here : 🡭
Collaborations/Partners/Scientific clients

Current content

National: Université de Lille, Université de Lyon, Université de Nantes, Université de Pau et des Pays de l'Adour International: Universidad Complutense de Madrid (Espagne)
Collaborations/Partners/Private Clients

Current content

Novance, Sanofi, Improve, Scient, URGO, Ocedis, Servier, SATT Nord
Services offers
Training offers

Current content

Organic Synthesis - Purification - Separation - Analyses - Characterization - Enzyme inhibition tests (IC50, Ki)
Services offers

Current content

Services for all our expertise: Synthesis, Chromatography (HPLC, LC-MS, IC-MS, IR)
Consulting services

Current content

We provide consulting services according to our expertise.
Equipments
Equipements spécifiques

Current content

  • Planetary ball mill machine
    P7PL/ FRITSCH
  • Vibrating ball mill machine
    SPEX Mixer Mill 8000M/ SPEX
  • ITC Calorimetry
    ITC 200/ MicroCal
  • MS-coupled ion chromatography
    ICS 6000/ Dionex
  • Catalytic Hydrogenation
    HCube/ Thales
  • Lyophilizer
    Christ alpha 1-4/ Bioblock
  • UV-Visible spectrophotometer
    V-630/ JASCO
Ecosystem
Affiliated institutions / organisations

Current content

  • University of Picardie Jules Verne (UPJV)
  • CNRS
Établissement(s) partenaire(s)

Current content

Unit(s) of attachment

Current content

Groups/Networks/Federations

Current content

SFR Condorcet EPNOE - European Polysaccharides Network of Excellence ICP - Institut Chimie de Picardie
Doctoral schools

Current content

Equipex/EquipEx+/ESR

Current content

Competitive cluster

Current content

Regional strategic areas of activity

Current content

  • Health and Nutrition
  • Chemistry and Materials
  • Green chemistry
  • Bioeconomy
  • Biobased chemistry
  • New therapeutic approaches
  • Sustainable production and mobilization of bioresources
  • Organic chemistry
  • Textiles, composites, materials
  • Biobased materials
Personal informations
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