• Health and Nutrition

Factors of persistence of leukemic cells (CANTHER)

Research team - UMR9020 CNRS – UMR1277 Inserm

Description

Our team focused on the discovery of factors that contribute to the long-term persistence of leukemia cells such as tumour dormancy, and the characterization of predictive genomic markers of the evolution of malignant blood diseases. Our results specifically highlighted the role of immuno-evasion (PD-L1, CCL2) and tumor stem cells. We are evaluating new genomic markers of malignant blood diseases, such as predictive markers of treatment failure and relapse. In collaboration with chemists, we are developing new methods to target protein/protein interactions in dormant tumour cells. We are also exploring new therapeutic strategies and developing new drugs targeting transcription factor/DNA interaction.

Contacts

  • Bruno Quesnel
    Contact

Informations

1 Place de Verdun, Bâtiment Cancer
Université de Lille, Campus Santé
59045 LILLE

http://canther.fr/fr/equipe-facteurs-de-persistance-des-cellules-leucemiques/

Expertises

Skills

• Mechanisms of tumor dormancy in leukemia
• Oncogenic transcription factors in leukemia and solid tumors
• Genetic and non-genetic factors
• Role of immune response in leukemia persistence
• Genetic, epigenetic and proteomic signature of dormant cells

Example(s) of publications

All our publications can be found here : 🡭

Services offers

Applications sectors

  • Science / Research

Ecosystem

Affiliated institutions / organisations

CHU de Lille
Inserm
University of Lille
CNRS
Centre Oscar Lambret
Institut Pasteur de Lille

Unit(s) of attachment

Doctoral schools

Regional strategic areas of activity

  • Health and Nutrition

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Thematics

Current thematics

  • Health and Nutrition
Title

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Factors of persistence of leukemic cells
Type

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Research team
Description

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Our team focused on the discovery of factors that contribute to the long-term persistence of leukemia cells such as tumour dormancy, and the characterization of predictive genomic markers of the evolution of malignant blood diseases. Our results specifically highlighted the role of immuno-evasion (PD-L1, CCL2) and tumor stem cells. We are evaluating new genomic markers of malignant blood diseases, such as predictive markers of treatment failure and relapse. In collaboration with chemists, we are developing new methods to target protein/protein interactions in dormant tumour cells. We are also exploring new therapeutic strategies and developing new drugs targeting transcription factor/DNA interaction.
Contact informations
Contact

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Contact name Email phone number
QUESNEL Bruno bruno.quesnel@chru-lille.fr (+33) 3 20 44 66 40
URL

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http://canther.fr/fr/equipe-facteurs-de-persistance-des-cellules-leucemiques/

Address

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1 Place de Verdun, Bâtiment Cancer
Université de Lille, Campus Santé
59045 LILLE
Keywords

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Cancer, tumor dormancy, persistence, hematological malignancies, leukemia, genomic markers, immunotherapy
Our search domains
Skills

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• Mechanisms of tumor dormancy in leukemia • Oncogenic transcription factors in leukemia and solid tumors • Genetic and non-genetic factors • Role of immune response in leukemia persistence • Genetic, epigenetic and proteomic signature of dormant cells
Workforce

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Example(s) of projects

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Example(s) of publications

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All our publications can be found here : 🡭
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Services offers
Training offers

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Services offers

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Consulting services

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Equipments
Equipements spécifiques

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Ecosystem
Affiliated institutions / organisations

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  • CHU de Lille
  • Inserm
  • University of Lille
  • CNRS
  • Centre Oscar Lambret
  • Institut Pasteur de Lille
Établissement(s) partenaire(s)

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Unit(s) of attachment

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  • Cancer Heterogeneity, Plasticity and Resistance to Therapies
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Doctoral schools

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Equipex/EquipEx+/ESR

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Competitive cluster

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Regional strategic areas of activity

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  • Health and Nutrition
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