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Health and Nutrition
Structural and Functional Glycobiology Unit (UGSF)
Research unit - UMR 8576
Our research aims to establish the link between the structure and function of glycans. In particular, we study the structure and function of complex carbohydrates associated with proteins or free polysaccharides as well as the enzymes involved in their biosynthesis and degradation. The main research topics of our laboratory cover a wide range of areas of interest, from the glycobiology of microorganisms and plant glycobiology to human health issues (glycopathologies). Our unit is composed of 10 teams articulated around 3 axes: structural glycobiology and modeling; biosynthesis, degradation of carbohydrates and their regulation; the function of carbohydrate molecules and their pathological disorders. We are open to all academic and industrial collaborations and propose services in line with our expertise.
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Yann Guerardel
Director -
Simon Hawkins
Assistant director
Bâtiment C9, Avenue Mendeleïev
Campus Cité Scientifique, Université de Lille
59655 VILLENEUVE D’ASCQ
http://ugsf-umr-glycobiologie.univ-lille1.fr/
Effectif
Effectif total : 174
Personnel d'appui à la recherche : 47
Skills
• Biosynthesis and degradation of glycans
• Glycans regulations
• Function of carbohydrate molecules and their pathological disturbances
• Glycobiology of olfaction
• Regulation of terminal glycosylation
• Microbial genetics
• Genetics of bacterial envelopes
• Heparan sulfate diversity and inflammatory response
• Molecular mechanisms of N-glycosylation and associated pathologies
• O-GlcNAcylation, signaling and cell cycle
• Vegetable fibers
• Computational molecular and systems biology
• Regulation of division signals
• Glycobiology in fungal and clinical applications
Example(s) of publications
• N. Yamakawa, J. Vanbeselaere, L.-Y. Chang, S.-Y. Yu, L. Ducrocq, A. Harduin-Lepers, J. Kurata, K.F. Aoki-Kinoshita, C. Sato, K.-H. Khoo, K. Kitajima, Y. Guerardel, Systems glycomics of adult zebrafish identifies organ-specific sialylation and glycosylation patterns, Nature Communications. 9 (2018). doi:10.1038/s41467-018-06950-3. 🡭
• Simon C, Lion C, Spriet C, Baldacci-Cresp F, Hawkins S, Biot C., One, Two, Three: A Bioorthogonal Triple Labelling Strategy for Studying the Dynamics of Plant Cell Wall Formation In Vivo Angew Chem Int Ed Engl. (2018) 57 doi: 10.1002/anie.201808493. 🡭
• Sendid B, Lecointe K, Collot M, Danzé PM, Damiens S, Drucbert AS, Fradin C, Vilcot JP, Grenouillet F, Dubar F, de Ruyck J, Jawhara S, Mallet JM, Poulain D.; Dissection of the anti-Candida albicans mannan immune response using synthetic oligomannosides reveals unique properties of β-1,2 mannotriose protective epitopes. Sci Rep. (2021) 11 doi: 10.1038/s41598-021-90402-4. 🡭
• Raab S, Gadault A, Very N, Decourcelle A, Baldini S, Schulz C, Mortuaire M, Lemaire Q, Hardivillé S, Dehennaut V, El Yazidi-Belkoura I, Vercoutter-Edouart AS, Panasyuk G, Lefebvre T.vCell Mol Life Sci.( 2021) doi: 10.1007/s00018-021-03857-z 🡭
Discover the full list of publications here.
Collaborations/Partners/Scientific clients
Institut Pasteur, Université Paris-Saclay
International:
Academia Sinica (Taïwan), Nagoya University (Japan), Sapienza University (Italy), Leuven University (Belgium), Marburg University (Germany)
Applications sectors
- Biotechnology
- Health / wellness
- Agri-food industry
- Science / Research
Services provided
• Mechanism of action studies
• Studies of the expression, biosynthesis and role of glycans
• Identification and synthesis of molecules for therapeutic use
• Identification of bioactive compounds
• Structural characterization of glycans and polysaccharides
• Molecular modeling
Training offers
• Introduction to microscopy
• Introduction to confocal microscopy
• FRET studies
Consulting services
Offres technologiques
- DIAGMASS : Diagnosis method, by mass spectrometry, in sera, for invasive fungal diseases
A "One Step" purification coupled to an analysis by mass spectrometry (MALDI TOF ) of human serum allows rapid, specific and highly sensitive detection of circulating fungal molecules (glycans). This method promotes early accurate diagnosis and favors an effective antifungal therapy, essential for patient survival. Read more
• BSL2 cell culture rooms
• qPCR machines
• mass spectrometer
• biochip analyzer
• liquid chromatography systems
• particle size analyzer
• pipetting robot
• biacore T200; Biacore 3000
• all basic equipment (cell culture equipment, cell and molecular biology, ultracentrifuges, freeze-dryers, homogenizers, spectrophotometers, etc.)
Affiliated institutions / organisations
Partner institution(s)
Groups/Networks/Federations
Doctoral schools
Competitive cluster
Regional strategic areas of activity
- Health and Nutrition
- Food ingredients