• Health and Nutrition

Laser Assisted Therapies and Immunotherapies for Oncology (OncoThAI)

Research unit - U 1189

Description

The activity of our unit is focused on the research and use of photo-dynamic therapy (PDT) for the treatment of certain cancers in therapeutic impasse. We draw on recognized expertise in medical imaging, simulation, treatment modelling and planning, and design, manufacturing and clinical evaluation of medical light devices to develop the technologies necessary for the implementation of PDT in human clinics. We also characterize the effects of PDT, used alone or in combination with conventional treatments, on the regulation of immune response. Open to both the industrial and academic worlds, we propose to meet your needs whatever your project.

Contacts

Informations

1, avenue Oscar Lambret
Campus Santé, Université de Lille
59037 LILLE

http://www.oncothai.fr/fr/

Laser Assisted Therapies and Immunotherapies for Oncology

Effectif

Effectif total : 49

Expertises

Skills

• Medical imaging
• Multimodality imaging
• Interventional imaging
• Medical lasers and photomedicine
• Photodynamic therapy (PDT)
• Oncology
• Illumination
• Immunoregulation
• Mathematical modelling of mechanisms (in-silico studies)
• In vitro and in vivo studies of the effects of PDT
• Planning, simulation
• Dosimetry of light
• Medical device design
• Clinical studies (writing protocols, submission to authorities,...)

Example(s) of projects

• Development of luminous textiles
• Development of 4 clinical protocols (FLEXITHERALIGHT, PHOSITOS, MesoPDT, and INDYGO)

Example(s) of publications

Leroy HA et al., Interstitial Photodynamic Therapy for Glioblastomas: A Standardized Procedure for Clinical Use, Cancers (Basel), 2021
• Dahlqvist G. et al., Modulatory effect of rapamycin and tacrolimus on monocyte-derived dendritic cells phenotype and function, Immunobiology, 2021
• Milhem C. et al., Combination of High Dose Hypofractionated Radiotherapy with Anti-PD1 Single Dose Immunotherapy Leads to a Th1 Immune Activation Resulting in a Complete Clinical Response in a Melanoma Patient, Int J Mol Sci., 2020

Collaborations/Partners/Scientific clients

Several national and international collaborations:

National:
AOC, PSLRA UMR 7274

International:
University Hospital UZ Leuven (Belgium), Tampere University of Technology (Finland), KVEST Recklinghausen (Germany), Abramson Cancer Center (USA), Roswell Cancer Park Institute (USA)

Services offers

Applications sectors

  • Health / wellness
  • Education / Training
  • Science / Research

Services provided

• Mathematical modelling of the light-biological tissue interaction
• Development of processing planning software
• Evaluation of the effectiveness of PDT on tumor cells
• Assessing the impact of PDT on immune system modulation
• Evaluating the impact of a drug candidate or cancer therapy molecule on regulatory T cells

Consulting services

We provide consulting services on all our skills

Ecosystem

Affiliated institutions / organisations

CHU de Lille
Inserm
University of Lille

Groups/Networks/Federations

SFR Technologies de Santé et Médicament

Doctoral schools

Regional strategic areas of activity

  • Health and Nutrition
    • New therapeutic approaches

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Thematics

Current thematics

  • Health and Nutrition
    • New therapeutic approaches
Title

Current content

Laser Assisted Therapies and Immunotherapies for Oncology
Type

Current content

Research unit
Description

Current content

The activity of our unit is focused on the research and use of photo-dynamic therapy (PDT) for the treatment of certain cancers in therapeutic impasse. We draw on recognized expertise in medical imaging, simulation, treatment modelling and planning, and design, manufacturing and clinical evaluation of medical light devices to develop the technologies necessary for the implementation of PDT in human clinics. We also characterize the effects of PDT, used alone or in combination with conventional treatments, on the regulation of immune response. Open to both the industrial and academic worlds, we propose to meet your needs whatever your project.
Contact informations
Contact

Current content

URL

Current content

http://www.oncothai.fr/fr/

Address

Current content

1, avenue Oscar Lambret
Campus Santé, Université de Lille
59037 LILLE
Keywords

Current content

Photodynamic therapy, Photosensitizers, Lasers, Cancers, Immunology, Medical imaging, Dosimetry, Oncology, Medical device design, Clinical studies
Our search domains
Skills

Current content

• Medical imaging • Multimodality imaging • Interventional imaging • Medical lasers and photomedicine • Photodynamic therapy (PDT) • Oncology • Illumination • Immunoregulation • Mathematical modelling of mechanisms (in-silico studies) • In vitro and in vivo studies of the effects of PDT • Planning, simulation • Dosimetry of light • Medical device design • Clinical studies (writing protocols, submission to authorities,...)
Workforce

Current content

Nombre de chercheurs :
Nombre de doctorants :
Nombre de personnel d'appui à la recherche :
Effectif total : 49
Example(s) of projects

Current content

• Development of luminous textiles • Development of 4 clinical protocols (FLEXITHERALIGHT, PHOSITOS, MesoPDT, and INDYGO)
Example(s) of publications

Current content

Leroy HA et al., Interstitial Photodynamic Therapy for Glioblastomas: A Standardized Procedure for Clinical Use, Cancers (Basel), 2021 • Dahlqvist G. et al., Modulatory effect of rapamycin and tacrolimus on monocyte-derived dendritic cells phenotype and function, Immunobiology, 2021 • Milhem C. et al., Combination of High Dose Hypofractionated Radiotherapy with Anti-PD1 Single Dose Immunotherapy Leads to a Th1 Immune Activation Resulting in a Complete Clinical Response in a Melanoma Patient, Int J Mol Sci., 2020
Collaborations/Partners/Scientific clients

Current content

Several national and international collaborations: National: AOC, PSLRA UMR 7274 International: University Hospital UZ Leuven (Belgium), Tampere University of Technology (Finland), KVEST Recklinghausen (Germany), Abramson Cancer Center (USA), Roswell Cancer Park Institute (USA)
Collaborations/Partners/Private Clients

Current content

Services offers
Training offers

Current content

Services offers

Current content

• Mathematical modelling of the light-biological tissue interaction • Development of processing planning software • Evaluation of the effectiveness of PDT on tumor cells • Assessing the impact of PDT on immune system modulation • Evaluating the impact of a drug candidate or cancer therapy molecule on regulatory T cells
Consulting services

Current content

We provide consulting services on all our skills
Equipments
Equipements spécifiques

Current content

Ecosystem
Affiliated institutions / organisations

Current content

  • CHU de Lille
  • Inserm
  • University of Lille
Établissement(s) partenaire(s)

Current content

Unit(s) of attachment

Current content

Groups/Networks/Federations

Current content

SFR Technologies de Santé et Médicament
Doctoral schools

Current content

Equipex/EquipEx+/ESR

Current content

Competitive cluster

Current content

Regional strategic areas of activity

Current content

  • Health and Nutrition
  • New therapeutic approaches
Personal informations
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