• Health and Nutrition

Laboratory of Virology

Research unit - ULR 3610

Description

Our laboratory studies the mechanisms involved in the pathogenesis of enteroviral infections and in the development of type 1 diabetes. We are also looking for ways to control these infections. Enterovirus infections are studied through the coxsackievirus B4 (CVB4) serotype used as a model.

Contacts

  • Didier Hober
    Director

Informations

Centre Paul Boulanger, Boulevard du Professeur Jules Leclerc,
Hôpital Albert Calmettte, CHRU Lille
59037 LILLE

Effectif

Effectif total : 15

Personnel de recherche : 5

Personnel d'appui à la recherche : 4

Expertises

Skills

• Conventional, molecular and serological virology
• Enterovirus and in particular coxsackievirus B4
• Viral parthogenesis of type 1 diabetes
• In vitro and in vivo models (animals)
• Detection and identification of enteroviruses
• Culture in anaerobic environment (fermentations), gnotobiology
• Pathogenesis of viral infection
• Infection control and prevention. Viral inactivation (virucidal tests)
• Viral infection markers

Collaborations/Partners/Scientific clients

National:
Arts et Métiers ParisTech, INRIA

International:
Université d'Exeter (UK), Université de Tampere (Finland), Université de Liège (Belgium), Université Monastir (Tunisia), LIMMS (Japan), CHU Brazzaville (Congo)

Services offers

Applications sectors

  • Science / Research

Services provided

• Detection and quantification of enteroviruses in biological media (isolation in cell culture)
• Detection of enterovirus RNA in biological media (RT-PCR, semi-nested RT-PCR) and quantification of enterovirus RNA (quantitative real-time RT-PCR).
• Detection of anti-enterovirus antibodies in biological media
• Development of anti-enterovirus antibody detection tests
• Detection of human and murine type 1 IFN by biological method.
• Antiviral activity tests of molecules and products against enteroviruses
• Virucidal activity tests of molecules and products against different families of viruses
• Analysis of the intestinal flora (cultivable and non-cultivable bacteria)
• Bacterial translocation in animals with controlled or conventional flora (NOD, DBA1, C3H)

Consulting services

We provide consulting services related to all our areas of expertise.

Equipments

We possess a wide range of equipment, including:
• BSL2 and BSL2 + with PSM2 and CO2 incubators: cell and virus culture
• Thermal cyclers and real-time PCR machine
• Plate reader and washer (ELISA)
• Delayed fluorescence reader (DELFIA)
• UV microscope (fluorescence and immunofluorescence)
• Electrophoresis, chromatography (gel filtration, affinity)
• Ultracentrifuge
• Anaerobic chamber, isolators, fermenters

Ecosystem

Affiliated institutions / organisations

CHU de Lille
University of Lille

Doctoral schools

Regional strategic areas of activity

  • Health and Nutrition
    • New therapeutic approaches
    • Prevention, well-being and the silver economy

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Thematics

Current thematics

  • Health and Nutrition
    • New therapeutic approaches
    • Prevention, well-being and the silver economy
Title

Current content

Laboratory of Virology
Type

Current content

Research unit
Description

Current content

Our laboratory studies the mechanisms involved in the pathogenesis of enteroviral infections and in the development of type 1 diabetes. We are also looking for ways to control these infections. Enterovirus infections are studied through the coxsackievirus B4 (CVB4) serotype used as a model.
Contact informations
Contact

Current content

Contact name Email phone number
HOBER Didier didier.hober@univ-lille.fr (+33) 3 20 44 66 88
URL

Current content

Address

Current content

Centre Paul Boulanger, Boulevard du Professeur Jules Leclerc,
Hôpital Albert Calmettte, CHRU Lille
59037 LILLE
Keywords

Current content

Virus, pathogenesis, enterovirus, antibodies, type 1 diabetes, virucide, persistence, viral inactivation, prevention, infections
Our search domains
Skills

Current content

• Conventional, molecular and serological virology • Enterovirus and in particular coxsackievirus B4 • Viral parthogenesis of type 1 diabetes • In vitro and in vivo models (animals) • Detection and identification of enteroviruses • Culture in anaerobic environment (fermentations), gnotobiology • Pathogenesis of viral infection • Infection control and prevention. Viral inactivation (virucidal tests) • Viral infection markers
Workforce

Current content

Nombre de chercheurs : 5
Nombre de doctorants :
Nombre de personnel d'appui à la recherche : 4
Effectif total : 15
Example(s) of projects

Current content

Example(s) of publications

Current content

Collaborations/Partners/Scientific clients

Current content

National: Arts et Métiers ParisTech, INRIA International: Université d'Exeter (UK), Université de Tampere (Finland), Université de Liège (Belgium), Université Monastir (Tunisia), LIMMS (Japan), CHU Brazzaville (Congo)
Collaborations/Partners/Private Clients

Current content

Services offers
Training offers

Current content

Services offers

Current content

• Detection and quantification of enteroviruses in biological media (isolation in cell culture) • Detection of enterovirus RNA in biological media (RT-PCR, semi-nested RT-PCR) and quantification of enterovirus RNA (quantitative real-time RT-PCR). • Detection of anti-enterovirus antibodies in biological media • Development of anti-enterovirus antibody detection tests • Detection of human and murine type 1 IFN by biological method. • Antiviral activity tests of molecules and products against enteroviruses • Virucidal activity tests of molecules and products against different families of viruses • Analysis of the intestinal flora (cultivable and non-cultivable bacteria) • Bacterial translocation in animals with controlled or conventional flora (NOD, DBA1, C3H)
Consulting services

Current content

We provide consulting services related to all our areas of expertise.
Equipments
Equipements spécifiques

Current content

  • Thermocyclers and PCR automation in real time
  • Electrophoresis, chromatography (gel filtration, affinity)
  • Ultracentrifuge
  • Delayed fluorescence reader
    DELFIA
  • UV microscope (fluorescence and immunofluorescence)
Ecosystem
Affiliated institutions / organisations

Current content

  • CHU de Lille
  • University of Lille
Établissement(s) partenaire(s)

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Unit(s) of attachment

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Groups/Networks/Federations

Current content

Doctoral schools

Current content

Equipex/EquipEx+/ESR

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Competitive cluster

Current content

Regional strategic areas of activity

Current content

  • Health and Nutrition
  • New therapeutic approaches
  • Prevention, well-being and the silver economy
Personal informations
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