• Health and Nutrition

Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases (EGENODIA)

Research unit - UMR 1283/8199

Description

The goal of our unit is to identify new genes involved in diabetes and obesity, and to better diagnose the forms of diabetes and obesity of genetic origin, thus allowing personalized medicine according to the genetic subtype. Our work also aims to better stratify the genetic and environmental risk factors, as well as the primary genetic causes, of metabolic diseases at different ages of life. We are developing translational concepts to allow individualized therapies for obese and diabetic patients. Different "multiomics" approaches are carried out using our unique genomics platform LIGAN-PM (high throughput DNA and RNA sequencing, genotyping and transcriptomic analysis using DNA chips, digital molecular counting via NanoString technology).

Contacts

  • Philippe Froguel
    Director
  • Gilles Pulvermuller

Informations

1, place de Verdun
Faculté de Médecine - Pôle Recherche, Université de Lille
59045 LILLE

http://www.good.cnrs.fr/

Effectif

Effectif total : 82

Personnel de recherche : 28

Personnel d'appui à la recherche : 40

Expertises

Skills

• Genetics of metabolic diseases
• Prediction, prevention and therapy of diabetes and obesity
• Personalized therapy for metabolic diseases
• Genetics and epigenetics of diabetes and obesity
• Molecular bases and modeling of diabetes and obesity
• Preparation and management of BioBanque
• High throughput sequencing (NGS) + analyzes (bioinformatics & biostatistics)

Example(s) of projects

• ERC Reg-Seq: Functional genomics of non-coding mutations in regulatory regions of four metabolic tissues, and their involvement into type 2 diabetes through large-scale sequencing
• PreciDiab National Center for Precision Diabetic Medicine

Example(s) of publications

• Vaxilaire M et al. Monogenic diabetes characteristics in a transnational multicenter study from Mediterranean countries, Diabetes Res Clin Pract. 2021 Jan;171:108553. 🡭
• Bonnefond A and Froguel P., Clustering for a better prediction of type 2 diabetes mellitus, Nat Rev Endocrinol. 2021 Feb 1. 🡭
• Bonnefond A et al. Pathogenic Variants in Actionable MODY Genes are Associated With Type 2 Diabetes, Nat Metab. 2020 Oct;2(10):1126-1134. 🡭
• Baron M et al. Loss-of-Function Mutations in MRAP2 are Pathogenic in Hyperphagic Obesity with Hyperglycemia and Hypertension, Nat Med. 2019 Nov;25(11):1733-1738. 🡭
• Khamis A et al. Histone Deacetylase 9 Promoter Hypomethylation Associated with Adipocyte Dysfunction is a Statin-Related Metabolic Effect. Clin Epigenetics 2020 May 14;12(1):68. 🡭

See the full list of publications here.

Collaborations/Partners/Scientific clients

National:
PARCC (Université de Paris), Université de Nice, ...

International:
Imperial College London (UK), University of Jena (Germany), Lund University (Sweden), University of Oxford (UK), Harvard University (USA), Leiden University (Netherlands), Helmholtz Association (Germany), Wellcome Centre for Human Genetics (UK), Shriners Hospitals for Children (USA), ...

Collaborations/Partners/Private Clients

Numerous collaborations with the pharmaceutical industry and biotechnology companies: Sanofi, Servier, Eli Lilly, Enterome, etc.
2 RHU in progress: iMAP with private partners ILTOO Pharma and IMMUNOTECH BECKMAN COULTER and PreciNASH with SANOFI

Services offers

Applications sectors

  • Science / Research

Services provided

• Preparation and extraction of DNA, RNA from blood or tissue, saliva and cell pellet
• Genotyping
• Expression analysis
• NGS sequencing
• Bioinformatics and statistical analysis

Consulting services

We provide consulting services related to all our areas of expertise.

Equipments

Biological materials

• Cell lines: murine and human beta cell models
• Murine models: Knock-out tissue specific, overexpression, physiological model for metabolic perturbations analysis ...
• Biological collections: DNA from different patient cohorts

Ecosystem

Affiliated institutions / organisations

Inserm
University of Lille
CNRS
Institut Pasteur de Lille

Partner institution(s)

CHU de Lille

Groups/Networks/Federations

PreciDIAB - Centre National de Médecine de Précision des Diabètes

Equipex/EquipEx+/ESR

Doctoral schools

Competitive cluster

Regional strategic areas of activity

  • Health and Nutrition
    • Food ingredients
    • New therapeutic approaches

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Thematics

Current thematics

  • Health and Nutrition
    • Food ingredients
    • New therapeutic approaches
Title

Current content

Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases
Type

Current content

Research unit
Description

Current content

The goal of our unit is to identify new genes involved in diabetes and obesity, and to better diagnose the forms of diabetes and obesity of genetic origin, thus allowing personalized medicine according to the genetic subtype. Our work also aims to better stratify the genetic and environmental risk factors, as well as the primary genetic causes, of metabolic diseases at different ages of life. We are developing translational concepts to allow individualized therapies for obese and diabetic patients. Different "multiomics" approaches are carried out using our unique genomics platform LIGAN-PM (high throughput DNA and RNA sequencing, genotyping and transcriptomic analysis using DNA chips, digital molecular counting via NanoString technology).
Contact informations
Contact

Current content

Contact name Email phone number
FROGUEL Philippe philippe.froguel@univ-lille.fr (+33) 3 74 00 81 00
PULVERMULLER Gilles gilles.pulvermuller2@univ-lille.fr (+33) 3 74 00 80 81
URL

Current content

http://www.good.cnrs.fr/

Address

Current content

1, place de Verdun
Faculté de Médecine - Pôle Recherche, Université de Lille
59045 LILLE
Keywords

Current content

genetics, (epi)genetics, obesity, diabetes, cell biology, personalized medicine, metabolic diseases, physiopathologies, molecular mechanisms, endocrinology
Our search domains
Skills

Current content

• Genetics of metabolic diseases • Prediction, prevention and therapy of diabetes and obesity • Personalized therapy for metabolic diseases • Genetics and epigenetics of diabetes and obesity • Molecular bases and modeling of diabetes and obesity • Preparation and management of BioBanque • High throughput sequencing (NGS) + analyzes (bioinformatics & biostatistics)
Workforce

Current content

Nombre de chercheurs : 28
Nombre de doctorants :
Nombre de personnel d'appui à la recherche : 40
Effectif total : 82
Example(s) of projects

Current content

• ERC Reg-Seq: Functional genomics of non-coding mutations in regulatory regions of four metabolic tissues, and their involvement into type 2 diabetes through large-scale sequencing • PreciDiab National Center for Precision Diabetic Medicine
Example(s) of publications

Current content

• Vaxilaire M et al. Monogenic diabetes characteristics in a transnational multicenter study from Mediterranean countries, Diabetes Res Clin Pract. 2021 Jan;171:108553. 🡭 • Bonnefond A and Froguel P., Clustering for a better prediction of type 2 diabetes mellitus, Nat Rev Endocrinol. 2021 Feb 1. 🡭 • Bonnefond A et al. Pathogenic Variants in Actionable MODY Genes are Associated With Type 2 Diabetes, Nat Metab. 2020 Oct;2(10):1126-1134. 🡭 • Baron M et al. Loss-of-Function Mutations in MRAP2 are Pathogenic in Hyperphagic Obesity with Hyperglycemia and Hypertension, Nat Med. 2019 Nov;25(11):1733-1738. 🡭 • Khamis A et al. Histone Deacetylase 9 Promoter Hypomethylation Associated with Adipocyte Dysfunction is a Statin-Related Metabolic Effect. Clin Epigenetics 2020 May 14;12(1):68. 🡭 See the full list of publications here.
Collaborations/Partners/Scientific clients

Current content

National: PARCC (Université de Paris), Université de Nice, ... International: Imperial College London (UK), University of Jena (Germany), Lund University (Sweden), University of Oxford (UK), Harvard University (USA), Leiden University (Netherlands), Helmholtz Association (Germany), Wellcome Centre for Human Genetics (UK), Shriners Hospitals for Children (USA), ...
Collaborations/Partners/Private Clients

Current content

Numerous collaborations with the pharmaceutical industry and biotechnology companies: Sanofi, Servier, Eli Lilly, Enterome, etc. 2 RHU in progress: iMAP with private partners ILTOO Pharma and IMMUNOTECH BECKMAN COULTER and PreciNASH with SANOFI
Services offers
Training offers

Current content

Services offers

Current content

• Preparation and extraction of DNA, RNA from blood or tissue, saliva and cell pellet • Genotyping • Expression analysis • NGS sequencing • Bioinformatics and statistical analysis
Consulting services

Current content

We provide consulting services related to all our areas of expertise.
Equipments
Equipements spécifiques

Current content

  • High throughput sequencers and peripheral devices -DNA/RNA chip scanner
    NovaSeq6000, 2xMiseq, NextSeq, Iseq100, HiSeq 4000, 2xHiseq 2500 & Iscan/ Illumina
  • Cellular energy metabolism system
    XFe24 Analyser/ Seaorse Agilent
  • Kinase assay system
    PamStation 12/ Pamgene
  • Single cell and RNASeq system
    ICELL8 cx Single-Cell/ TAKARA
  • Mass Spectrophotometer System
    Orbitrap Exploris 240 Vanquish Duo/ Thermo Fischer
  • Slide scanner
    NanoZOOMER / HAMAMATSU
  • Robotic Platforms
    Sciclone G3, Chemagic 2x Bravo, 2xStarlet 8…/ PerkinElmer, Agilent, Hamilton
  • Targeted DNA / RNA Quantification System
    nCounter Analysis System/ NanoString
  • Sequencer Sanger / RT-PCR
    3730 xl , QuantStudio 7/ Life Technologies
  • Calculation Server Infrastructure
    Serveurs GPU , Parabricks…/ DELL
Ecosystem
Affiliated institutions / organisations

Current content

  • Inserm
  • University of Lille
  • CNRS
  • Institut Pasteur de Lille
Établissement(s) partenaire(s)

Current content

CHU de Lille
Unit(s) of attachment

Current content

Groups/Networks/Federations

Current content

PreciDIAB - Centre National de Médecine de Précision des Diabètes
Doctoral schools

Current content

Equipex/EquipEx+/ESR

Current content

Competitive cluster

Current content

Regional strategic areas of activity

Current content

  • Health and Nutrition
  • Food ingredients
  • New therapeutic approaches
Personal informations
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